Synthesis and Optimization of Cell-permeable Contrast Agents for Magnetic Resonance Imaging

Synthesis and Optimization of Cell-permeable Contrast Agents for Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a technique widely used in both clinical and experimental settings to produce high-resolution images of opaque living organisms without utilizing ionizing radiation. Currently, MR imaging is augmented by contrast agents; however, these small molecule Gd(III) chelates are confined to extracellular and vascular regions of the specimen, reducing their ability to provide information about cell physiology or molecular pathology. However, as compared to other imaging modalities, MRI has a relatively low sensitivity to exogenous contrast agents. As a result, the system has an inherent difficulty exploiting any newly developed contrast agent, especially if the probe shows specificity and selective image contrast enhancement on a molecular level.HPLC was accomplished using a Varian Prostar system. Two Prostar 210 pumps with 25 mL/min heads fed a 5 mL manual inject sample loop. ... Cell Culture Experiments PC3M (human prostate cancer) and PC12 (rat pheochromocytoma) cells were grown according to the instructions recommended by American Typeanbsp;...


Title:Synthesis and Optimization of Cell-permeable Contrast Agents for Magnetic Resonance Imaging
Author: Paul Joseph Endres
Publisher:ProQuest - 2008
ISBN-13:

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