The Modulation of Magnetic Properties in Magnetic Resonance Imaging Contrast Agents Using Enzymes

The Modulation of Magnetic Properties in Magnetic Resonance Imaging Contrast Agents Using Enzymes

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Magnetic resonance imaging (MRI) is an advanced imaging modality that is experiencing increasing popularity in clinical and experimental settings. MRI enjoys the benefit of high-resolution, the use of non-ionizing radiation, and the ability to distinguish between soft tissues. MR imaging is enhanced with the use of Gd3+ chelated contrast agents; however the current commercially available contrast agents for MRI are low relaxivity, monomeric vascular agents. A new generation of MR contrast agents has been developed that addresses the need for these agents to respond to localized biological environments. This thesis expands upon a family of enzyme-activable MR contrast agents.performed on the Varian INOVA 126 MHz NMR using a 10mm broadband carbon probe. ... The preparative LC is the Varian Prostar model 210 consisting of two 210 pumps with 25 ml/min heads with a 5 ml manual injection sample loop.


Title:The Modulation of Magnetic Properties in Magnetic Resonance Imaging Contrast Agents Using Enzymes
Author: Paul June Hyung Lee
Publisher:ProQuest - 2008
ISBN-13:

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